Sympathomimetic ionotrope, stimulating both α and β receptors. Unfortunately, the drug is also proarrythmic and increases the HR, both of which are undesirable effects. Bile acid sequesterant (BAS), representative of its class.
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It binds to D-Alanyl-D-Alanine portion of the peptidoglycan and prevents it from being transported to the cell wall for cross-linking. Resistance may arise by replacing the terminal D-Ala to Lactate, preventing one https://soberhome.net/14-celebrities-in-recovery-famous-faces-whove/ of the hydrogen bonds from forming. This agent was originally isolated from streptomyces and turned out to be effective against 98% of the 31,000 species it was tested against and to inhibit most ß-lactamases.
- HCTZ is the drug of choice for initial hypertensive therapy per the ALLHAT study.
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- The drug is notorious for drug interactions due to its narrow therapeutic window.
- The class as a whole moderately lowers LDL and may have some positive effects on HDL.
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Adalimumab is indicated for the treatment of rheumatoid arthritis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis, among several other conditions. Ustekinumab is indicated for the treatment of moderate to severe plaque psoriasis and active psoriatic arthritis. Levetiracetam is an anticonvulsant for the treatment of myoclonic, partial, and tonic-clonic seizures.
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In clinical studies, ombitasvir, paritaprevir, and ritonavir with dasabuvir was shown to cure 95% to 100% of subjects who took the combination with or without ribavirin. Artemether/lumefantrine (Coartem) is indicated for the treatment of acute, uncomplicated malaria infections due to Plasmodium falciparum. The US Centers for Disease Control and Prevention also recommends the drug as a first-line therapy for this indication. A cell wall biosynthesis inhibitor used in MRS and other infections from Gram positive bacteria.
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Resistance can develop to the diuretic effect. Some efficacy can be recovered if a loop/thiazide combination is employed. However, once the dosages are maxed renal https://rehabliving.net/how-alcohol-can-affect-your-heart-rate-the-new/ patients will usually require dialysis. Furosemide is not the loop of choice during exacerbations of CHF, due to a more erratic absorption in this state.
Reduces platelet count through an unknown mechanism. Indicated for myeloproliferative disorders. Common side effects include; edema, palpitations, GI distress, dizziness, dyspnea and fever. To test yourself on the top 250 drugs, download our adaptive-learning flashcard and quiz mobile app for iPhone/iPad called FlashRX. Clindamycin (brand name Cleocin) is a lincosamides. This combination of 4 antiretroviral medications is indicated for the treatment of genotype 1 chronic hepatitis C virus.
HCTZ is the drug of choice for initial hypertensive therapy per the ALLHAT study. Its mechanism of action in HTN is through vasodilatation and not diuresis. An α-1 adrenergic antagonist representative of its class. Doxazosin results in arterial and venous vasodilation without reflex tachycardia.
It is available in a sulfate salt (83% quinidine), gluconate salt (62% quinidine) and a polygalactate salt (60% quinidine). The most common side effect is diarrhea, but torsades is a real possibility due to the widening of QRS interval. Quinidine interacts with both digoxen and warfarin increasing their systemic concentrations. Unlike Dobutamine, Milrinone provides non-receptor mediated ionotropy.
Works similarly to ACE-Is, however, ARBs do not block bradykinin breakdown thus there is less propensity to cause the dry cough side effect. Research has shown there to be benefit when ARBs are used in combination with ACE-I or as initial therapy. However, the class is usually reserved for patients that fail ACE-I antibiotics and alcohol due to the fact that ACE-I are more cost-effective. When used in combination with potassium sparing diuretics or ACE-I hyperkalemia can occur. Interestingly, while the dry cough should not occur mechanistically, patients still report cough while on ARBs. A Vitamin K antagonist in the class of coumarins.
If you get a pronunciationfrom more than one source, and 2 or more don’t match, you will endup guessing. What you find might becrowd-sourced, computer-generated, someone’s best guess, or thereal deal. Researching pronunciations on the internet can be time-consuming and lead to the wrong answer. If you get a pronunciation from more than one source, and 2 or more don’t match, you will end up guessing. What you find might be crowd-sourced, computer-generated, someone’s best guess, or the real deal.
Most important side effect is rhabdomyolosis, which usually presents as chest/upper body muscle aches. Drug should be Discontinued if this occurs. Pronouncingdrug names correctly will help you feel confident, avoid criticism,earn trust, improve safety, and feel less frustrated.